Found 10 hits of ic50 for drug = Hydrochlorothiazide W/ Hydralazine Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Peroxisomal acyl-coenzyme A oxidase 1
(Homo sapiens) | BDBM81461
(CAS_86-54-4 | Hydralazine | Hydralazine (HZN) | NS...)Show InChI InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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MCE
MMDB
PC cid
PC sid
PDB
UniChem
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| | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Myeloperoxidase
(Homo sapiens (Human)) | BDBM81461
(CAS_86-54-4 | Hydralazine | Hydralazine (HZN) | NS...)Show InChI InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Libre de Bruxelles
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed b... |
J Med Chem 60: 6563-6586 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00285
BindingDB Entry DOI: 10.7270/Q27D2XD7 |
More data for this
Ligand-Target Pair | |
Myeloperoxidase
(Homo sapiens (Human)) | BDBM81461
(CAS_86-54-4 | Hydralazine | Hydralazine (HZN) | NS...)Show InChI InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Libre de Bruxelles (ULB)
Curated by ChEMBL
| Assay Description
Irreversible inhibition of MPO (unknown origin) |
ACS Med Chem Lett 8: 206-210 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00417
BindingDB Entry DOI: 10.7270/Q28K7C3H |
More data for this
Ligand-Target Pair | |
Myeloperoxidase
(Homo sapiens (Human)) | BDBM81461
(CAS_86-54-4 | Hydralazine | Hydralazine (HZN) | NS...)Show InChI InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Libre de Bruxelles (ULB)
Curated by ChEMBL
| Assay Description
Inhibition of human MPO |
ACS Med Chem Lett 8: 206-210 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00417
BindingDB Entry DOI: 10.7270/Q28K7C3H |
More data for this
Ligand-Target Pair | |
Lactoperoxidase
(Bos taurus (Bovine)) | BDBM81461
(CAS_86-54-4 | Hydralazine | Hydralazine (HZN) | NS...)Show InChI InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12) | PDB
UniProtKB/SwissProt
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| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Libre de Bruxelles
Curated by ChEMBL
| Assay Description
Inhibition of bovine milk LPO assessed as reduction in NaOSCN production in presence of H2O2/NaSCN after 5 mins |
J Med Chem 60: 6563-6586 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00285
BindingDB Entry DOI: 10.7270/Q27D2XD7 |
More data for this
Ligand-Target Pair | |
Myeloperoxidase
(Homo sapiens (Human)) | BDBM81461
(CAS_86-54-4 | Hydralazine | Hydralazine (HZN) | NS...)Show InChI InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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DrugBank
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MCE
MMDB
PC cid
PC sid
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UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Libre de Bruxelles
Curated by ChEMBL
| Assay Description
Inhibition of recombinant MPO (unknown origin) assessed as reduction in LDL oxidation in presence of H2O2 and HCl after 5 mins by ELISA |
J Med Chem 60: 6563-6586 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00285
BindingDB Entry DOI: 10.7270/Q27D2XD7 |
More data for this
Ligand-Target Pair | |
Aspartate aminotransferase, cytoplasmic
(Homo sapiens) | BDBM81461
(CAS_86-54-4 | Hydralazine | Hydralazine (HZN) | NS...)Show InChI InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12) | PDB
UniProtKB/SwissProt
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MCE
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PC cid
PC sid
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| Article
PubMed
| n/a | n/a | 2.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128883
BindingDB Entry DOI: 10.7270/Q2668J40 |
More data for this
Ligand-Target Pair | |
Aspartate aminotransferase, cytoplasmic
(Homo sapiens) | BDBM81461
(CAS_86-54-4 | Hydralazine | Hydralazine (HZN) | NS...)Show InChI InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
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DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128883
BindingDB Entry DOI: 10.7270/Q2668J40 |
More data for this
Ligand-Target Pair | |
N-glycosylase/DNA lyase
(Homo sapiens (Human)) | BDBM81461
(CAS_86-54-4 | Hydralazine | Hydralazine (HZN) | NS...)Show InChI InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
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DrugBank
MCE
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PC cid
PC sid
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| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Oregon Health & Science University
| Assay Description
A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi... |
ACS Chem Biol 10: 2334-43 (2015)
Article DOI: 10.1021/acschembio.5b00452
BindingDB Entry DOI: 10.7270/Q22F7M6H |
More data for this
Ligand-Target Pair | |
Bile salt export pump
(Homo sapiens (Human)) | BDBM81461
(CAS_86-54-4 | Hydralazine | Hydralazine (HZN) | NS...)Show InChI InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12) | PDB
UniProtKB/SwissProt
antibodypedia
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MCE
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PC cid
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| Article
PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-... |
Drug Metab Dispos 40: 2332-41 (2012)
Article DOI: 10.1124/dmd.112.047068
BindingDB Entry DOI: 10.7270/Q2ZP488M |
More data for this
Ligand-Target Pair | |
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